Angloma, a right back during his career in Europe, scored the first goal from 10 yards in the 17th minute. Two minutes later, Richard Socrier put Guadeloupe two goals ahead with a thundering header. Carlos Pavon scored the only Honduran goal in the 70th minute.
Once again, Mexico put on a subpar performance, but it escaped from Houston's Reliant Stadium with a 1-0 win in overtime over Costa Rica, which finished the game with eight players.
Jared Borgetti, the Tri's all-time leading scorer, scored the game's only goal on a header in the 97th minute. Costa Rica, which had Alan Aleman sent off late in the first half, lost Alvaro Saborio and Mario Camacho on red cards later in overtime.
The Guadeloupe-Honduras and Mexico-Costa Rica doubleheader drew 70,092 fans at Reliant Stadium.
In the first game of Saturday's doubleheader at Foxboro's Gillette Stadium, Canada cruised past Guatemala, 3-0. Ali Gerba scored two goals and set up a third in the first half for Canada, which advanced to the semifinals for the first time since 2002 when it lost to the United States. Canada and the United States meet in the opening semifinal on Thursday.
Gerba, who plays for Swedish club IFK Gothenburg, set up Houston Dynamo star Dwayne De Rosario for the first goal in the 17th minute before putting the game away with two goals of his own.