Brad Friedel was in goal for Blackburn in a winning effort on the road, beating Middlesbrough, 2-1.
All three Americans -- starters Brian McBride and Carlos Bocanegra and sub Clint Dempsey -- were in action for Fulham, which held a 1-0 lead from the first minute at the Emirates Stadium until six minutes remaining but ended up losing to Arsenal, 2-1.
Jonathan Spector started on the backline in West Ham's 2-0 loss to Manchester City.
DaMarcus Beasley had another solid performance for Rangers in a 2-0 win over St. Mirren in his Scottish Premier League debut at Ibrox.
Heath Pearce made his Bundesliga debut in Hansa Rostock's 3-0 loss to Bayern Munich.
In the German Second Division, Josh Wolff had two assists in 1860 Munich's 6-2 win at Augsburg.
Neven Subotic, only 18, went the entire 90 minutes in Mainz's 4-1 victory over Koblenz.