Keller was beaten on an own goal and in the 90th minute by Shaun Maloney.
Reading's American goalkeeper Marcus Hahnemann also came out on the losing end, 3-0 at Bolton, in a game that saw Bobby Convey enter for Reading in the 63rd minute.
Two American keepers faced off as Everton (Tim Howard) and Blackburn (Brad Friedel) played to a 1-1 tie. Both made good saves in the stalemate
Eddie Lewis' debut with Derby ended in a 2-1 home loss to Birmingham City.
Jonathan Spector stayed on the West Ham bench in a 1-1 tie with Wigan Athletic.