The Spartans dropped their second straight 2-0 decision, falling at Cincinnati in non-conference action.
It's been a long season for the Bearcats (7-9-1) after winning their first Big East divisional title in 2006, but they took care of Michigan State thanks to goals by Noah Davidson and Kenny Anaba on either side of halftime.
No. 4 Brown, No. 6 Boston College, No. 9 Indiana, No. 14 UC Santa Barbara, No. 17 Duke and No. 19 West Virginia all won on the road.
BC needed a golden goal by Ghanaian Reuben Ayarna to dispose of Holy Cross, 2-1, in Worcester.
Indiana was the big winner, scoring all four goals in a 4-0 rout of Kentucky in the first 58 minutes.
Senior Brennan Tennelle scored his first two goals of the season to lead defending national champion UCSB to a 3-1 at UC Irvine that improved the Gauchos to 6-1-1 in the Big West.
No. 15 Cal Poly and No. 22 Ohio State had to settle for ties with Cal State Northridge and Louisville, respectively.