The Caribbean tournament, which is taking place in six venues in Trinidad & Tobago, will qualify one team to the 2008 CONCACAF Champions Cup.
Former Colorado Rapids player Fabrice Noel scored four goals, while Panamanian Alberto Zapata added three more for Islanders.
Five goals came in a six-minute span before and after halftime.
In the other Group C encounter in Marabella, Gerard Adensida and Bryen Damaba scored for Surinam's Inter Moengotapoe in a 2-1 victory over Harbour View FC of Jamaica.
The Islanders and Inter Moengotapoe, who meet Thursday, are tied for first place in Group C with four points after two games. The top two teams advance to the quarterfinals that begin Sunday.
Nov. 6 in Marabella
Puerto Rico Islanders 10 Hitachi Centre Sap FC (Antigua & Barbuda) 0. Goals: Herrera 2, Noel 11, 45, 47, 48, Zapata 45, 51, 74, Velez 72, Delgado 88.
Puerto Rico Islanders -- Behonick, Velez, Rivera, Miranda (Avila), Ortiz, Villegas (Delgado, 60), Noel, Atieno (Zapata, 43), Segovia, Herrera, Steele.
Hitachi Centre Sap FC -- Aaron, Challenger (Brooks, 57), Mack, Williams, Christian, Tonge, Parker, Limerick, Luke (Charles, 61), McKel, Samuel (Murray, 54).
Referee: Royon Small (Barbados).