America is assured of its worst half-season in history and its worst overall record for a full season in 30 years.
Chivas was already ahead 2-0 at the Jalisco Stadium when America's Juan Carlos Silva was ejected. Sergio Avila added a third goal for Guadalajara shortly afterwards before Paraguay striker Salvador Cabanas scored twice to make the score respectable.
In late March, Club America president Guillermo Canedo, son of the late FIFA executive of the same name, and Coach Ruben Omar Romano announce their resignations, effective in June.
America's domestic troubles come as it enters a critical stage in the Libertadores Cup. Its 4-3 win over Argentina's River Plate two days after the resignation of Canedo and Romano moved it into a tie for first place with River Plate in their Libertadores Cup group.
America's Libertadores Cup future will be on the line Thursday when it plays Chile's Universidad Catolica in Santiago.