The 5-4 victory on aggregate sent America, last in the overall standings of the recently completed Mexican First Division Clausura regular season, on to the quarterfinals and marked the end of Joel Santana's reign at Flamengo. The veteran coach will take up his new job as head coach of 2010 World Cup host South Africa.
Coached by interim coach Juan Antonio Luna, America took a 2-0 halftime lead and won the return leg on stocky Paraguay forward Salvador Cabanas' second goal of the evening in the 78th minute.
"From happiness to chaos," was the headline in the sports daily Lance, which described the defeat as an "historic embarrassment."
Atlas of Guadalajara also advanced, beating Lanus of Argentina, 3-2, on aggregate to give Mexico two teams in the quarterfinals.
Flamengo's archrival, Fluminense, had better luck, beating Atletico Nacional of Colombia, 1-0, to advance, 3-1, on aggregate.
Also advancing to next week's quarterfinals were Brazilian clubs Sao Paulo, the defending champion, and Santos, Boca Juniors and San Lorenzo of Argentina and LDU Quito of Ecuador.