Defending champion Santos now has a 2-1-2 win-loss-tie record and is sixth in the overall standings, and second in Group 1 behind Atlante..
Leading the overall standings, with five wins and a tie, is San Luis, whose Californian defender Michael Orozco is back from Olympic duty but did not see action in a 1-0 win over Tigres.
Pachuca's Texan midfielder Jose Francisco Torres was a second-half sub in a 3-1 loss to Pumas. Pachuca is winless after five games.
Two other Texans saw action last weekend.
Daniel Hernandez went 90 minutes for Jaguares in a 3-2 win at Club America.
Marco Antonio Vidal played the first half in Indios' 1-1 draw over Toluca.