Yacine Bezzaz, Rafik Saifi and Anthar Yahia scored for the Desert Foxes. Colorado Rapids keeper Bouna Coundoul was on the bench for Senegal.
In Friday's other qualifiers, Libya upset Ghana, 1-0, to open a three-point lead over the Black Stars at the top of Group 5. (Ghana's Chelsea star, Michael Essien was injured in the game.) Malawi moved into a share of the lead in Group 12 with a 3-0 win at Djibouti.