Their teammate on the U.S. defense, Carlos Bocanegra, is expected to start for French club Rennes against Twente.
Neven Subotic, who has three goals in four Bundesliga games for Borussia Dortmund, is set to make his European debut against Italy's Udinese.
In Tuesday's action, California Ryan Guy started for Irish upstart St. Patrick's in its 2-0 loss to Hertha Berlin.
Nine Americans are on teams in the UEFA Cup.
YANKS IN UEFA CUP:
Borussia Dortmund (Neven Subotic) vs. Udinese
Everton (Tim Howard) vs. Standard Liege (Oguchi Onyewu)
Hertha Berlin (Bryan Arguez) vs. St. Patrick's (Ryan Guy)
Litex vs. Aston Villa (Brad Friedel, Brad Guzan)
Rennes (Carlos Bocanegra) vs. Twente
Young Boys vs. Club Brugge (Jared Jeffrey)