The defending national champion Dallas Texans Red got a fight from Laguna Hills Eclipse Black but prevailed, 2-1, thanks to goals by Alyssa Diggs and Amanda Frisbie.
Eclipse Select only needed Erin Pekovich's goal in the eighth minute for a 1-0 win over Houston area giant Challenge.
Vardar beat Blue Valley Soccer Club Stars Mallorca, 2-0, while the McLean MPS Dragons downed Ela Elite, 3-0.
The Dallas Texans Red Dallas, winners of last year's National League and National Championships, opened the new campaign with a 2-1 win over Team Boca. Anna Cuffina put the Florida team ahead with the a goal in the 13th minute, but the Texans rallied to win on goals by Clarissa Wedemeyer and Kelley Monogue in the second half.
The Montclair United Thunderbolts debuted with a 2-1 win over Southern California powerhouse Slammers FC thanks to goals from Lauren Manna and Gabriella Galanti.
The So Cal Blues edged the Scorpions Elite, 1-0, and Cleveland FC and Eclipse Select, the Chicago area powerhouse, played to a 1-1 draw.
In their National League debut, the Wall Wombats defeated the Michigan Hawks Black, 2-0, on early goals by Rebecca Dinis and Christina Camassa.
The defending U.S. Youth Soccer national champion San Juan Spirits Blue were held to a 1-1 tie by the D'Feeters. The Dallas Texans Red and San Diego Surf also played to a 1-1 tie. The third tie in the division was a 0-0 deadlock between the NSA Fury and FC Pennsylvania Strikers.
Eclipse Select (IL) 1, Challenge (STX) 0
Goal: Erin Pekovich (8)
Vardar (MI) 2, BVSC Stars Mallorca (KS) 0
Goals: Nichole Read (31), Angela Gerback (89)
Dallas Texans Red Girls-Dallas (NTX) 2, Laguna Hills Eclipse Black (CA-S) 1
Goals: Texans: Alyssa Diggs (42), Amanda Frisbie (84)l Laguna: Gabrielle Arganda (10)
McLean MPS Dragons (VA) 3, Ela Elite (IL) 0
Goals: Melissa Downey (8), Jennifer Skugerboe (33), Briana Hovington (66)
Dallas Texans Red-Dallas (NTX) 2, Team Boca (FL) 1
Goals: Texans: Clarissa Wedemeyer (44), Kelley Monogue (59); Boca: Anna Cuffina (13)
Montclair United Thunderbolts (NJ) 2, Slammers FC (CA-S) 1
Goals: Thunderbolts: Lauren Manna (40), Gabriella Galanti (59); Slammers: Tessa Andujar (18)
So Cal Blues-Dodge (CA-S) 1, Scorpions Elite (MA) 0
Goal: Callan Parra (24)
Cleveland FC (OH-N) 1, Eclipse Select (IL) 1
Dallas Texans Red (NTX) 1, San Diego Surf White (CA-S) 1
Goal: Dallas Texans Red: Angelica Garcia (1); Surf: Alexandra Bailey (38)
D'Feeters (NTX) 1, San Juan Spirits Blue (CA-N) 1
Goals: D'Feeters: Lauren Bateman (79); Spirits: Haley Washburn (68)
Wall Wombats (NJ) 2, Michigan Hawks Black 0
Goals: Rebecca Dinis (13), Christina Camassa (17)
NSA Fury (IL) 0, FC Pennsylvania Strikers (EPA) 0