Mexico, which opened the final round of Concacaf World Cup qualifying, the Hexagonal, with a 2-0 loss to the USA in Ohio on Feb. 11, faces Costa Rica March 28 in their next qualifier.
Mexico coach Sven-Goran Eriksson fielded a squad without his European-based players: Keeper Guillermo Ochoa, Oscar Rojas, Leobardo Lopez, Julio Cesar Dominguez, Fausto Pinto; Fernando Arce, Leandro Augusto, Gerrardo Torrado, Israel Martinez; Matias Vuoso, Omar Bravo.
Argentine native Vuoso opened the scoring in the 24th minute. Six minutes later, Bolivia's Juan Manuel Pena was sent off for a slicing down Vuoso from behind. Pena's foul set up a free kick from 25 yards out that Augusto rocketed Bolivia's goal.
Vuoso scored from close range to give Mexico a 3-0 lead in the 58th minute, sub Sergio Santana scored from the penalty spot in the 71st minute, and debutant Jose Maria Cardenas scored after a penalty area scramble in the 84th minute.
Didi Torrico scored Bolivia's lone goal in the 69th minute.