Columbus (0-1-1) vs. Toronto FC (1-0-0) (4 p.m. ET, Direct Kick).
TFC got off to great start in Kansas City and that potent midfield will be fun to watch, but the Crew beat Toronto a year ago in its home opener. Déjà vu, baby!
Prediction: Crew 2, TFC 1.
D.C. United (0-0-1) vs. Chicago (1-0-0) (7:30 p.m, Direct Kick)
Fire defenders Bakary Soumare and Gonzalo Segares will be missing because of international duty yet the United back line is no great shakes, either.
Prediction: United 2, Fire 2.
New York (0-1-0) vs. New England (1-0-0), (7:30 p.m., FSC, FSE)
The last three meetings have ended, 1-1, and the odds might indicate a change is on order. So be it.
Prediction: Red Bulls 0, Revs 0.
Colorado (0-1-0) vs. Kansas City (0-1-0) (9:30 p.m., Direct Kick)
Kansas City won only two road games last year but has enough firepower to open up the Rapids, and can only improve defensively from last week.
Prediction: Rapids 1, Wizards 2.
San Jose (0-1-0) vs. Houston (0-0-1) (10:30 p.m., Direct Kick)
The Quakes are still sorting out their midfield issues and that's where the Dynamo is most dangerous, yet set plays may rule the day.
Prediction: Quakes 1, Dynamo 1.
Seattle (1-0-0) vs. Real Salt Lake (0-0-0) (10:30 p.m. Direct Kick)
The Sounders have a lot more going for them than just the Fredy Montero Mojo and RSL is cooked unless it can get back into FieldTurf mode quickly.
Prediction: Sounders 2, RSL 0.
FC Dallas (0-1-0) vs. Chivas USA (1-0-0) (3 p.m., TeleFutura)
FCD has Kenny Cooper, Chivas USA doesn't have Sacha Kljestan, and both teams have questions in goal.
Prediction: FCD 3, Chivas 1.
(All times ET)
Last week's record: 2-5. Season: 2-5.
A tough first week offers plenty of upside, as in room for improvement! A pick of every home team would hit at about 50 percent, but where's the fun in that?
Score: Houston 1, Columbus 1.
Prediction: Houston 1, Columbus 1.
Score: FC Dallas 1, Chicago 3.
Prediction: FC Dallas 0, Chicago 2.
Score: Kansas City 2, Toronto FC 3.
Prediction: Kansas City 3, Toronto FC 1.
Score: San Jose 0, New England 1.
Prediction: San Jose 2, New England 2.
Score: Chivas USA 2, Colorado 1.
Prediction: Chivas USA 2, Colorado 2.
Score: Chivas USA 2, Colorado 2.
Prediction: Los Angeles 3, D.C. United 2.