The Gunners, who earned a 1-1 draw in Spain last week, have won five EPL games in a row and have reached the semifinals of the FA Cup against Chelsea on Saturday at Wembley.
With Cesc Fabregas back in action and Robin van Persie and Emmanuel Adebayor in fine form, Arsenal has the talent to go far.
Of concern, though, are injuries to goalie Manuel Almunia and French defenders William Gallas and Gael Clichy.
Arsenal -- 21-Fabianski; 3-Sagna, 5-Toure, 20-Djourou, 18-Silvestre; 15-Denilson, 17-Song, 4-Fabregas, 14-Walcott; 8-Nasri; 25-Adebayor.
Villarreal -- 13-D.Lopez; 18-A.Lopez, 4-Godin, 2-Rodriguez, 5-Capdevila; 10-Cani, 21-Soriano, 6-Eguren, 11-Ibagaza; 16-Llorente, 22-Rossi.