The Tri faces Trinidad & Tobago Wednesday in Mexico City in a battle of the last two teams in Concacaf's World Cup 2010 qualifying group.
Big changes are expected after Mexico's 2-1 loss at El Salvador on Saturday, most notably in midfield where Pavel Pardo and Gerardo Torrado are suspended.
Oscar Perez was Mexico's third goalie in its four Hexagonal matches, and he could be replaced by Guillermo Ochoa.
Other changes should be Carlos Salcido's return to the starting lineup from suspension at right back
In midfield, Israel Castro of champion UNAM should get the start, but there are doubts about the fitness of Cuauhtemoc Blanco and Nery Castillo.
Of perhaps more importance to the USA's hopes of qualifying for South Africa is Wednesday's other Hexagonal match between Honduras and El Salvador. A tie or El Salvador win would very much be the USA's interest.
Julio Cesar de Leon will return to the Honduran lineup after missing the Catrachos' 2-1 loss to the USA because of suspension.
U.S. referee Baldomero Toledo will be in charge of the match at the Stadio Olimpico Metropolitano in San Pedro Sula.