The announcement of the network, which will air games in the UEFA Champions League, English Premier League and Italy's Serie A, was made on Tuesday.
Fox Sports International will have to negotiate with cable and satellite providers for access. Fox Soccer Plus will be a premium service.
Fox launched its first soccer channel, now called Fox Soccer Channel, in 1997.
Last week, many listings of English Premier League matches and promotional ads for Champions League coverage were dropped from the broadcast schedules on Setanta Sports North America's Web site amid speculation Setanta may be taken over by Fox Sports International or discontinued.
Setanta also lost an EPL property last year to ESPN, which airs early Saturday games and Monday matches that had been telecast by Setanta in past years.