"After a great deal of thought and prayer," Adair said in a statement released by the school, "I believe the time is right to pursue other opportunities in coaching and to help transition the Clemson program to new leadership."
Adair, 48, was released on a $10,000 personal recognizance bond after being charged with two counts of assault and battery of a high and aggravated nature following an incident that took place on an early Saturday morning.
Police responded to reports of a fight and were told by witnesses that Adair struck his two daughters several times, causing minor injuries, according to the Daily Journal/Messenger.
"We had many bright moments at Riggs Field during his tenure and we wish him the best in his future endeavors," Clemson Athletic Director Terry Don Phillips said in a statement.
Adair has a 208-115-33 record in 18 seasons as a head coach at Brown and Clemson. He led the Tigers to the 2005 Men's College Cup semifinals and five appearances in the NCAA Division I quarterfinals.