The Fire fell to the Wilmington Hammerheads, 1-0, Tuesday at Legion Stadium in Wilmington, N.C., on a goal by Kenny Bundy in the 37th minute.
Chicago fielded many of its regulars but was unable to answer that goal, scored when defender Tim Karalexis played a long ball that Bundy took past the Fire defense and shot past goalie Andrew Dykstra.
Wilmington, a USL-2 team, upset the USL-1 Carolina RailHawks in the second round and gets another USL-1 opponent, the Rochester Rhinos, in the quarterfinals to be played next week.
June 30 in Wilmington, N.C.
Wilmington (USL-2) 1, Chicago (MLS) 0
Goal: Bundy (Karalexis) 37.
Wilmington -- Sattler, Karalexis (Thayer 82), Falvey, Walters, Tatters, Bundy (Solle 75), Briggs, Dombrowski, Murray, Bagley (Hufstader 61), Watson.
Chicago -- Dykstra, Prideaux (Tim Ward 29), Soumare, Woolard, Washington (Pappa 68), Banner, Husidic, Lowry (Rolfe 76), Mapp, Nyarko, Dimitrov.