UPDATE: U.S. XI vs. Ecuador: Guzan, Yedlin, Birnbaum, Brooks, Johnson, Bradley, Beckerman, Jones, Zardes, Dempsey, Zusi.
1. First look at new backline.
Cameron and John Brooks are expected to be Klinsmann's first choice at center back. The other three options are Matt Besler, who started alongside Cameron for the first two games at the 2014 World Cup, Steve Birnbaum, who started with Cameron in the 4-0 win over Guatemala in March, and Michael Orozco, who started with Brooks in the 3-1 win over Puerto Rico on Sunday.
Brooks has started with Orozco five times but never played with Besler or Birnbaum. He played in the second half of the 2014 World Cup opener against Ghana with Cameron when he came on for the injured Besler and scored the winning goal.
If Fabian Johnson is healthy -- he was also kept out of the Puerto Rico game -- he should team up with DeAndre Yedlin on the outside. The only other natural outside back on the Copa Centenario roster is Timmy Chandler, but he just arrived in camp on Tuesday after finishing up in the German promotion-relegation playoffs. Given Chandler's situation, Kellyn Acosta was called in as cover.
2. Two or three in central midfield?
One of the decisions Klinsmann will have to make is whether to go with Michael Bradley and Jermaine Jones in central midfield or add a third central midfielder, Kyle Beckerman, as he did against Ghana in 2014 and Mexico in the 2015 Concacaf Cup.
It could be an option for the opening game against Colombia -- the most attack-minded of the three Group A opponents -- before Klinsmann switches to a more traditional 4-4-2 with Bradley and Jones teamed together like in the opening two World Cup 2018 qualifiers in November 2015.
3. Two or three up front?
Klinsmann faces the same decision -- two or three up front? Bobby Wood and Clint Dempsey started both March qualifiers against Guatemala, while Gyasi Zardes joined them for the second game in Columbus, which the USA won, 4-0.
Zardes has excellent for the LA Galaxy, pushing Jordan Morris down the U.S. depth chart up front, and could be merit another look against Ecuador.
USA vs. Ecuador:
GOALKEEPERS (3): Brad Guzan (Aston Villa, ENG), Tim Howard (Everton/ENG), Wiliam Yarbrough (Leon/MEX).
DEFENDERS (8): Kellyn Acosta (FC Dallas), Matt Besler (Sporting KC), Steve Birnbaum (D.C. United), John Brooks (Hertha Berlin, GER), Geoff Cameron (Stoke City, ENG), Timmy Chandler (Eintracht Frankfurt, GER), Michael Orozco (Tijuana, MEX), DeAndre Yedlin (Sunderland, ENG).
MIDFIELDERS (9): Kyle Beckerman (Real Salt Lake), Alejandro Bedoya (Nantes, FRA), Michael Bradley (Toronto FC), Fabian Johnson (Borussia M'Gladbach, GER), Jermaine Jones (Colorado Rapids), Perry Kitchen (Hearts, SCO), Darlington Nagbe (Portland Timbers), Christian Pulisic (Borussia Dortmund, GER), Graham Zusi (Sporting KC).
FORWARDS (4): Clint Dempsey (Seattle Sounders), Chris Wondolowski (San Jose Earthquakes), Bobby Wood (Hamburg, GER), Gyasi Zardes (LA Galaxy)