In 2019, four of the five teams advanced, including Sporting KC, a 5-0 winner over Mexico's Toluca on aggregate. The only loser was Toronto FC, which fell to tiny Panamanian club CA Independiente.
In 2020, three of the five MLS entrants -- Atlanta United, NYCFC and the Seattle Sounders -- should be favored while the other two series involving MLS teams will be toss-ups.
LAFC was drawn with Mexico's Leon, the lone unseeded Liga MX team, and the Montreal Impact under new head coach Thierry Henry will face Costa Rica's Saprissa, whose record against MLS teams in the Concacaf Champions League is 6-3-3.
Here's a look at the five MLS opponents ...
Leon was the only Mexican team in pot two, setting up the lone clash of MLS and Liga MX teams in the first round ... Las Esmeraldas qualified as the runner-ups in the 2019 Torneo Clausura ... In its only previous appearance in the Concacaf Champions League, Leon failed to get out of the group stage in 2014, finishing second behind Costa Rica's Herediano.
Players to watch: Mexican captain Luis Montes and Colombian Angel Mena form a dynamic duo in Leon's midfield.
Motagua (Atlanta United).
Motagua, from the Honduran capital city of Tegucigalpa, qualified for the Concacaf Champions League as a finalist in the 2019 Concacaf League, the qualifying competition that sent its top six teams to the Concacaf Champions League ... Since the Concacaf Champions League era began in 2008-09, it has qualified for the competition five times, most recently in 2018, but never reached the final eight ... Los Azules are the second most successful club in Honduras with 17 league titles.
Players to watch: Emilio Izaguirre has more than 100 caps for the Honduras national team that also features Motagua players Felix Crisanto, Marcelo Pereira, Marcelo Santos, Kevin Lopez and Hector Castellanos.
Olimpia (Seattle Sounders).
Olimpia has a long history in Concacaf play, winning the old Concacaf Champions Cup in 1972 and 1988 and finishing second in 1985 and 2000 ... It will be making its 11th appearance in the Concacaf Champions League, missing out only in 2019. No other team has made as many appearances ... It qualified for the 2020 Concacaf Champions League as a semifinalist in the Concacaf League,
Players to watch: Captain Ever Alvarado (28 caps) anchors the Olimpia's backline Its squad also includes some of the top Catracho U-23s, keeper Alex Guity and midfielders Carlos Pineda and Edwin Rodriguez.
San Carlos (NYCFC).
San Carlos won its first Costa Rican league title in 2019, a year after winning promotion to the top flight ... Los Toros del Norte are the northern-most team to ever win the Costa Rican championship ... They are one of four first-time entrants in the Concacaf Champions League, along with MLS's LAFC and NYCFC and Jamaica's Portmore United.
Players to watch: Jairo Arrieta, 36, spent five seasons in MLS with three different clubs. He was San Carlos' second-leading scorer this fall behind another MLS veteran, Alvaro Saborio, who retired after San Carlos lost in the Apertura semifinals to Saprissa. In goal is 37-year-old Patrick Pemberton, Costa Rica's backup keeper at the 2010 and 2014 World Cups.
Saprissa (Montreal Impact).
Saprissa qualified as the winner of the Concacaf League ... It is Costa Rica's most successful club with 34 league titles ... Los Morados won the old Concacaf Champions Cup three times, most recently in 2003.
Players to watch:
Johan Venegas spent two seasons with the Impact and two more at Minnesota United before returning to Costa Rica in 2018. Christian Bolanos, a veteran of three World Cups, spent two seasons with the Vancouver Whitecaps before returning for his third stint at Saprissa.