The game was first competitive match since former NWSL coach Laura Harvey took charge of the U-20s.
Even without U-20 star Sophia Smith, who turned pro and joined the NWSL's Portland Thorns, Harvey fielded an experienced team featuring plenty of international experience.
North Carolina's Brianna Pinto, the 2019 U.S. Soccer Young Female Player of the Year, and Virginia's Alexa Spaanstra, who both played in the 2018 U-20 Women's World Cup, combined for three goals.
Next Up: The U-20s play host Dominican Republic on Monday.
Feb. 22 in Santo Domingo
USA 9 Cuba 0. Goals: Fishel 9, 13, 42, 45+2, Pinto 16, 90, Spaanstra 37, Yates 67, Meza 68.
USA -- Dickey; DellaPeruta, Girma, Wesley, Holmes (Martinez, 65); Nighswonger, Duong, Pinto; Rodman, Fishel (Yates, 62), Spaanstra (Meza, 59).
Cuba -- Matamoro; Lopez (Suarez, 46), Cespedes, Aldana (Gongora, 74), Rodriguez, Valdez, Alvarez, Hernandez, Prats, Nunez (Mengana, 61), Borrego.