U.S. Open Cup: Most intriguing round-of-32 matchups

The last eight MLS entrants will enter the U.S. Open Cup this week when the tournament moves into the round of 32.

They join the 13 MLS teams who survived the third round. The rest of the field consists of teams from the USL Championship (5) and USL League One (4) and MLS Next Pro and NISA (1 each).

The most intriguing matchups:

Richmond Kickers vs. Charlotte FC: The  Kickers won the Open Cup in 1995, the last year before MLS's launch, and have beaten MLS teams five times. Charlotte FC, MLS's lone 2022 expansion team, is one of seven teams still alive playing in their first Open Cup campaign.

San Antonio FC vs. Houston Dynamo: San Antonio FC will look to knock off its second MLS Texas team in 2022 after beating Austin FC in the third round. In 2016, SAFC's first campaign ended with a 4-0 loss to the Dynamo.

Three lower-division teams are assured of reaching the final 16. Two matchups involve USL Championship teams -- Detroit City FC vs. Louisville City and Sac Republic FC vs. Phoenix Rising -- and the third -- Union Omaha vs. Northern Colorado -- involves teams from USL League One playing in their first Open Cup campaigns. All but the Rising have beaten MLS teams.

MLS vs. MLS:
Tuesday, May 10
Orlando City vs. Philadelphia Union 7 pm.
D.C United (3) vs. NY Red Bulls 7:30 pm.
Sporting KC (4) vs. FC Dallas (2) 8:30 pm.
LAFC vs. Portland Timbers 10:30 pm.
Wednesday, May 11
New England Revolution (1) vs. FC Cincinnati 7 pm.
*Nashville SC vs. Atlanta United (1) 8 pm.
Minnesota United vs. Colorado Rapids 8 pm.
Seattle Sounders (4) vs. San Jose Earthquakes 10 pm.

MLS vs. USL Championship:
Wednesday, May 11
Houston Dynamo (1) vs. San Antonio FC 8:30 pm.

MLS vs. USL League One:
Tuesday, May 10
*Inter Miami vs. South Georgia Tormenta FC 8 pm.
Wednesday, May 11
Richmond Kickers (1) vs. *Charlotte FC 6:30 pm.

MLS vs. MLS Next Pro:
Wednesday, May 11
New York City FC vs. *Rochester New York FC 7 pm.

MLS vs. NISA:
Wednesday, May 11
*Cal United Strikers vs. LA Galaxy (2) 10:30 pm.

USL Championship vs. USL Championship:
Tuesday, May 10
Detroit City FC vs. Louisville City 7:30 pm.
Wednesday, May 11
Sac Republic FC vs. Phoenix Rising 10;30 pm.

USL League One vs. USL League One:
Wednesday, May 11
*Union Omaha vs. *Northern Colorado 8 pm.
*First Open Cup campaign.
Note
: In parentheses are the number of Open Cup titles. Kickoff times: ET. Streaming: ESPN+.

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