Arsenal faces a stern test of its Premier League title credentials against Manchester United this weekend and Liverpool and Chelsea meet in a clash of two clubs desperate to escape mid-table obscurity. In a match between teams at the bottom of the standings, Frank Lampard takes Everton to face David Moyes' West Ham, with both managers under intense pressure as the relegation trap door looms.
Here's a look at some of the key talking points ahead of the action.
Arsenal's title charge
Arsenal vs. Manchester United used to be the match that defined the Premier League, pitting Arsene Wenger against Alex Ferguson in a rivalry for the ages. In recent years, the game has been reduced to a sideshow, but there is a growing sense that leader Arsenal can end a wait of nearly two decades to be crowned English champions, while United is a rising force under Erik ten Hag.
Mikel Arteta's young team is now clear favorite to claim Arsenal's first Premier League crown since the 2004 "Invincibles". The Gunners have more points at this stage of a league season than ever before and are benefiting from the stumbles of those beneath them, particularly the inconsistency of champions Manchester City.
Aside from the game against United and a match against City in February, Arsenal's league fixtures over the next two months look kind. Even so, Arteta believes a successful title campaign will "demand almost perfection."
Eight points behind Arsenal, Ten Hag's men travel to the Emirates Stadium without suspended midfielder Casemiro after the Brazilian was booked in the frustrating midweek draw at Crystal Palace.
Liverpool, Chelsea in clash of also-rans
After nearly two decades of sparring for silverware, the startling declines of Liverpool and Chelsea will be laid bare when they meet at Anfield on Saturday.
Just last season, Liverpool came within touching distance of an unprecedented quadruple, while Chelsea was the winner of the FIFA Club World Cup. Liverpool finished second in the Premier League and Chelsea came third, with the Reds beating the Blues in both the FA Cup and League Cup finals.
Those battles will seem like distant memories this weekend as ninth-placed Liverpool hosts 10th-placed Chelsea.
Both still harbor faint hopes of climbing into the top four, but with injuries hurting Jurgen Klopp's and Graham Potter's teams, gatecrashing the race to qualify for the Champions League looks a tough ask.
Klopp has achieved enough in his long reign to keep the critics largely at bay, but Chelsea's Potter is on shaky ground only four months after replacing the sacked Thomas Tuchel. Despite a huge spending spree under the club's new owners, Chelsea had lost seven of its previous 10 matches in all competitions prior to a 1-0 victory against Crystal Palace last weekend.
Potter could give a debut to Ukraine winger Mykhailo Mudryk after his £88 million ($108 million) move from Shakhtar Donetsk as he seeks to find the magic formula.
Lampard, Moyes on borrowed time
Everton manager Frank Lampard and West Ham boss David Moyes are fast running out of time heading into their important clash.
Either team could end Saturday at the bottom of the Premier League table depending on Southampton's result against Aston Villa, and neither will approach the game in London with much confidence. West Ham has taken just a single point from its past seven league games and Everton has one point from a possible 18.
Rumors have swirled this week that Moyes is likely to be dismissed if he loses the game. But the Hammers finished seventh last season and reached the Europa League semi-finals. Moyes has pleaded for loyalty from fans.
"What we've given West Ham supporters in the last few years, I hope they can give us back," he said.
Former Chelsea boss Lampard, for his part, says he will not "cry" at the pressure he is under.
Schedule:
Saturday: Liverpool vs Chelsea, Bournemouth vs Nottingham Forest, Leicester vs Brighton, Southampton vs Aston Villa, West Ham vs Everton, Crystal Palace vs Newcastle
Sunday: Leeds vs Brentford, Manchester City vs Wolves, Arsenal v Manchester Untied
Monday: Fulham vs Tottenham
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© Agence France-Presse