The match in Santo Domingo, the Dominican Republic capital, was originally scheduled to be played on Wednesday, but all Group A games were pushed back to to bad weather.
Sentnor, the U-20 captain, is the only player on the current team who played in the 2022 U-20 World Cup in Costa Rica, where the USA was eliminated in the group stage.
Jordynn Dudley, Kat Rader, Lauren Martinho and Ally Lemos (on the third penalty) also scored for the USA, which has won 15 games in a row in Concacaf U-20 play, dating back to the 2018 final, which it lost to Mexico on penalty kicks.
May 26 in Santo Domingo
USA 6 Panama 0. Goals: Dudley 1, Sentnor 41 pen., 49 pen., Rader 45, Martinho 64, Lemos 71 pen.
USA -- Wy; Thompson (Klenke, 73), Evans, Emri,King (Dellarose, 63); Lemos; Aikey (Martinho, 63), Harvey; Dudley (Gamero, 63), Sentnor (Cagle, 71), Rader.
Panama -- Garay; Montenegro (Hincapié, 46), Madrid, Rosas; Salazar (Capt.) (Name, 73), S.King (Espino, 63), Pon, Gil, Cargill, Rivera (Goldstein, 63), Gross (Rojas, 72).
Yellow Card: Panama -- Garay 29.
Referee: Katia Garcia (Mexico). ARs: Mayra Mora (MEX), Santa Medina (DOM), 4th Official: Astrid Gramajo (GUA). VAR: Benjamin Pineda (CRC). AVAR1: Ivan Barton (SLV)