The weekend kicks off with a clash of English Premier League leaders Manchester United and Chelsea. In MLS Week 2, D.C. United plays its home opener against New England, which also opened the season with a loss.

The first week of MLS's 15th season continues on Friday when Chivas USA hosts Colorado in a game aired on MLS's Direct Kick Package. New York plays its first league game in its new stadium when it hosts Chicago. Real Salt Lake opens its title defense in San Jose. The U.S. women host Mexico on Sunday.

Red Bull Arena's grand opening, in which the host welcomes Brazil's Santos, is aired Saturday by Fox Soccer Channel and Fox Sports en Espanol. ESPN broadcasts Real Madrid's game against Sporting Gijon on Saturday. The EPL's big game of the weekend is Manchester United's clash with Liverpool on Sunday. Argentina's biggest rivals meet on Sunday: Boca Juniors-River Plate.

The slate of weekend European league action kicks off on Friday with games from Germany and Italy. The U.S. U-17 girls national team continues its quest to qualify for the 2010 U-17 World Cup on Friday at the Girls U-17 Concacaf Championship.

Continental club championships highlight the midweek, including the start of the Concacaf Champions League knockout stage, in which MLS's Columbus Crew faces Toluca on Tuesday. In the Europan Champions League, David Beckham returns to Old Trafford to battle former club Manchester United on Wednesday.