Tuesday, April 4
Philadelphia Union 1 Atlas 0. (Goal: Gazdag 89 pen.)
Leon 5 Violette 0. (Goals: Mena 8, Davila 66, 84, Di Yorio 90+1, Hernandez 90+4.)
Wednesday, April 5
Motagua 0 Tigres 1. (Goal: Quinones 44.)
Vancouver Whitecaps 0 LAFC 3. (Goals: Bouanga 55, 65, Opoku 61.)
Note: Second legs will be played April 11-13.
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